This site is intended for healthcare professionals
Improving treatment options for childhood psoriasis

Welcome

Read time: 130 mins
Published:4th Jul 2020
Are you doing enough for your paediatric patients with moderate-to-severe psoriasis? The burden of psoriasis is greatest for our youngest patients, like Mia, but current treatment options are limited. Find out how that is set to change.

Meet our young patient Mia who suffers from psoriasis and is currently being managed by our team of paediatric psoriasis experts. Together we will be exploring the burden of childhood psoriasis for patients and their families, particularly the difficulties around diagnosis, comorbidities and limited treatment options. Mia’s treatment history helps us describe the current treatments available and we also look to the future for Mia using a summary of the clinical trials of more targeted treatments underway.

The World Health Organization defines psoriasis as a painful, disfiguring and disabling disease for which there is no cure and with great negative impact on patients’ quality of life (QoL)1. Prevalence in adults is 2–3%, but up to 30% of patients present with their first symptoms during childhood and adolescence, a critical point in the development of emotional and psychosocial well-being2. While milder forms of psoriasis are typically managed with topical therapies, patients with moderate-to-severe psoriasis generally require systemic or biologic therapy for which there are currently limited options available2.

Short of time? View a short expert interview with Professor Tiago Torres which covers all the key topics relevant to childhood psoriasis.

Video corrections: (i) Adalimumab (4yr) FDA should read Adalimumab (4yr) EMA; (ii) Ixekizumab3 and secukinumab4 have now received European approval for the treatment of moderate-to-severe plaque psoriasis in children over the age of six years (September 2020)

Click on the list icon in the video player (bottom, right-hand side) to directly access the answer to the below questions.

  1. How prevalent is paediatric psoriasis in your region? (00:10 - 00:44)
  2. What treatments are available for treating children with mild-to-moderate psoriasis? (00:44 - 01:04)
  3. What treatments are available for treating children with moderate-to-severe psoriasis? (01:04 - 02:11)
  4. Are physicians reluctant to consider biologics as a treatment option for children? (02:11 - 02:40)
  5. Is long-term efficacy and safety data with biologics still lacking? (02:40 - 03:38)
  6. Evolving treatment landscape in adult psoriasis and paediatric psoriasis (03:38 - 04:29)
  7. Biologic therapies currently approved (04:29 - 04:57)
  8. Biologic therapies currently being evaluated in clinical trials for paediatric psoriasis (04:57 - 05:31) 
  9. Will having well-controlled psoriasis in paediatric patients reduce the impact of psoriasis in later life? (05:31 - end).
Welcome:

References

  1. World Health Organization. Psoriasis. 2016. Available at: https://www.who.int/publications-detail/global-report-on-psoriasis. Accessed 27 April 2020.

  2. Paller AS, Singh R, Cloutier M, Gauthier-Loiselle M, Emond B, Guérin A, et al. Prevalence of psoriasis in children and adolescents in the United States: A claims-based analysis. J Drugs Dermatology. 2018;17(2):187–194.

  3. Taltz® Summary of Product Characteristics. 2020. Available at https://www.medicines.org.uk/emc/product/8199/smpc#gref

  4. Cosentyx® Summary of Product Characteristics. 2020. Available at https://www.medicines.org.uk/emc/product/3669/smpc#gref