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Oral Anticoagulation Reversal

Oral Anticoagulants

Read time: 40 mins
Last updated:12th Mar 2020
This section provides information on the various options available for oral anticoagulation. With oral vitamin K antagonists (VKAs) and non-vitamin K oral anticoagulants (NOACs) being covered, you'll be able to understand the merits and drawbacks of individual treatments, such as warfarin, rivaroxaban and edoxaban, in detail.

Details of the effects that VKAs can have on patients with atrial fibrillation, heart failure, valvular heart disease, venous thromboembolism and transient ischaemic attacks; the use of paracetamol and an adjuvant therapy; how the CYP2C9 and VKORC1 genes affect blood coagulation; and details of non-vitamin K oral anticoagulants, such as factor Xa inhibitors, rivaroxaban, apixaban, edoxaban, and the factor IIa inhibitor dabigatran are all included in this section.

Oral Vitamin K Antagonists

Oral vitamin K antagonists (VKAs) and non-vitamin K oral anticoagulants (NOACs) are prescribed to prevent or treat excessive blood coagulation, however, they can also be used to treat conditions such as valvular heart disease, heart failure and atrial fibrillation. 

 

VKAs include warfarin, acenocoumarol and phenprocoumon; NOACs include the Factor Xa inhibitors rivaroxaban, apixaban and edoxaban, and the Factor IIa (thrombin) inhibitor dabigatran. 

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Non-Vitamin K Oral Anticoagulants

A focused update of the 2010 ESC guidelines for the management of AF was issued in 2012. [Camm et al., 2012] This was partly in response to positive phase III clinical trial data with the NOACs dabigatran, rivaroxaban and apixaban, [Patel et al., 2011; Granger et al., 2011; Connolly et al., 2009] 

and their subsequent approval for stroke prevention in at-risk patients with non-valvular AF. Comparable data for edoxaban was not available at the time of publication.

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Oral Anticoagulants References

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